Studies of streptococcal fibrinolysis; the inhibition of streptococcal fibrinolysis by antifibrinolysin and antiprotease.

Studies of streptococcal fibrinolysis; a quantitative method for the estimation of serum antifibrinolysin.

Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion

Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bac...

The relationship between acute rheumatism and streptococcal antifibrinolysin.

That haemolytic streptococci of human origin produce a substance capable of liquefying human fibrin was first demonstrated by Tillet and Garner in 1933. The fibrin from patients recently recovered from haemolytic streptococcal infection was in many cases found to be resistant to the action of this fibrinolysin. and confirmed these preliminary observations, and demonstrated antifibrinoly-sin in ...

Prediction of T-cell epitopes for designing a reverse vaccine against streptococcal bacteria

Streptococcal bacteria are among dangerous human pathogens with major prevalence worldwide. A good vaccine against streptococcal bacteria should have epitopes that confer protection from infection by different streptococcal bacteria types. we aimed was to recognize the most immunogenic and conserved epitopes of streptococcal bacteria, which could be a potential candidate for vaccine development...

Streptococcal Fibrinolysis: a Proteolytic Reaction Due to a Serum Enzyme Activated by Streptococcal Fibrinolysin

1. Methods for the preparation and partial purification of streptococcal fibrinolysin are described. 2. The lysis of fibrin clots in the presence of streptococcal fibrinolysin is associated with proteolysis of the fibrin. Digestion is due to an enzyme normally present in serum or plasma in an inactive state, which is activated by fibrinolysin. Fibrinolysin alone has no demonstrable proteolytic ...